{
    "biomarker_id": "AN6383-1",
    "biomarker_canonical_id": "AN6383",
    "condition": {
        "recommended_name": {
            "id": "DOID:1612",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1612",
            "name": "breast cancer",
            "description": "An organ system cancer that originates in the mammary gland."
        },
        "synonyms": [
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "breast tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant neoplasm of breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant tumor of the breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
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                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
    "biomarker_component": [
        {
            "biomarker": "increased GGT level",
            "assessed_biomarker_entity_id": "P19440-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Glutathione hydrolase 1 proenzyme",
                "synonyms": [
                    {
                        "synonym": "Gamma-glutamyltranspeptidase 1"
                    },
                    {
                        "synonym": "GGT 1"
                    },
                    {
                        "synonym": "2.3.2.2"
                    },
                    {
                        "synonym": "Leukotriene-C4 hydrolase"
                    },
                    {
                        "synonym": "3.4.19.14"
                    },
                    {
                        "synonym": "Gamma-glutamyltransferase 1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "76625-3"
                }
            ],
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                    "id": "AN6383-1",
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                    "url": "https://biomarkerkb.org/biomarker/AN6383-1"
                },
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                    "url": "https://glygen.org/publication/PubMed/25043373",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Several prospective studies have demonstrated associations between GGT or ALT and risk of type 2 diabetes mellitus, cardiovascular disease, vascular and nonvascular mortality, and all cause mortality outcomes. Emerging evidence indicates that increasing levels of GGT and ALT may each be linked to cancer risk. A number of prospective studies have been published reporting on the associations between baseline levels of these enzymes and risk of cancer, but their results have been inconsistent, particularly for ALT. Whereas some studies have observed positive associations of circulating levels of these enzymes with risk of cancer, others have shown inverse associations, with some studies showing no associations at all."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6383-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6383-1"
        },
        {
            "id": "25043373",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/25043373",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Several prospective studies have demonstrated associations between GGT or ALT and risk of type 2 diabetes mellitus, cardiovascular disease, vascular and nonvascular mortality, and all cause mortality outcomes. Emerging evidence indicates that increasing levels of GGT and ALT may each be linked to cancer risk. A number of prospective studies have been published reporting on the associations between baseline levels of these enzymes and risk of cancer, but their results have been inconsistent, particularly for ALT. Whereas some studies have observed positive associations of circulating levels of these enzymes with risk of cancer, others have shown inverse associations, with some studies showing no associations at all."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6383-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6383-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Gamma glutamyltransferase, alanine aminotransferase and risk of cancer: systematic review and meta-analysis.",
            "journal": "International journal of cancer",
            "authors": "Kunutsor Setor K, Apekey Tanefa A, Van Hemelrijck Mieke, Calori Giliola, Perseghin Gianluca",
            "date": "2015-03-01",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25043373",
                    "url": "https://glygen.org/publication/PubMed/25043373"
                }
            ],
            "evidence": [
                {
                    "id": "AN6384-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6383-1"
                }
            ]
        }
    ],
    "section_stats": [
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                }
            ],
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                "assessed_biomarker_entity.recommended_name"
            ]
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}