{
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    "biomarker_canonical_id": "AN6351",
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            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
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            },
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            },
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            },
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            },
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            },
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            },
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            },
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            },
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                "resource": "MONDO",
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                "description": ""
            },
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "beta-CoV",
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            },
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                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased ALB level",
            "assessed_biomarker_entity_id": "P02768-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Albumin",
                "synonyms": []
            },
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                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "35706-1"
                }
            ],
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury."
                        }
                    ]
                },
                {
                    "id": "32304745",
                    "database": "PubMed",
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                    "tags": [
                        "assessed_biomarker_entity",
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                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Decreased albumin (p <0.001), and increased lactate dehydrogenase (LDH) (p <0.001) at admission were significantly associated with severe and critical disease conditions (Table 3)."
                        }
                    ]
                },
                {
                    "id": "32296824",
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19."
                        }
                    ]
                },
                {
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "Albumin levels could be used as an independent predictor of the risk of nonsurvivors in critically ill patients with COVID-19."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6351-1",
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            "id": "32048163",
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                "best_biomarker_role",
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            ],
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                {
                    "evidence": "The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury."
                }
            ]
        },
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            "url": "https://glygen.org/publication/PubMed/32304745",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Decreased albumin (p <0.001), and increased lactate dehydrogenase (LDH) (p <0.001) at admission were significantly associated with severe and critical disease conditions (Table 3)."
                }
            ]
        },
        {
            "id": "32296824",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32296824",
            "tags": [
                "best_biomarker_role",
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            ],
            "evidence_list": [
                {
                    "evidence": "We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19."
                }
            ]
        },
        {
            "id": "32490680",
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            "evidence_list": [
                {
                    "evidence": "Albumin levels could be used as an independent predictor of the risk of nonsurvivors in critically ill patients with COVID-19."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6351-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6351-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.",
            "journal": "Science China. Life sciences",
            "authors": "Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L",
            "date": "2020",
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                    "id": "AN6350-3",
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                    "url": "https://biomarkerkb.org/biomarker/AN6351-1"
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            ]
        },
        {
            "title": "Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China.",
            "journal": "Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases",
            "authors": "Zhang J, Wang X, Jia X, Li J, Hu K, Chen G, Wei J, Gong Z, Zhou C, Yu H, Yu M, Lei H, Cheng F, Zhang B, Xu Y, Wang G, Dong W",
            "date": "2020",
            "reference": [
                {
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                    "url": "https://glygen.org/publication/PubMed/32304745"
                }
            ],
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                {
                    "id": "AN6351-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6351-1"
                }
            ]
        },
        {
            "title": "A Tool for Early Prediction of Severe Coronavirus Disease 2019 (COVID-19): A Multicenter Study Using the Risk Nomogram in Wuhan and Guangdong, China.",
            "journal": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
            "authors": "Gong J, Ou J, Qiu X, Jie Y, Chen Y, Yuan L, Cao J, Tan M, Xu W, Zheng F, Shi Y, Hu B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
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        },
        {
            "title": "Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.",
            "journal": "Biomarkers in medicine",
            "authors": "Li J, Li M, Zheng S, Li M, Zhang M, Sun M, Li X, Deng A, Cai Y, Zhang H",
            "date": "2020",
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