{
    "biomarker_id": "AN6309-2",
    "biomarker_canonical_id": "AN6309",
    "condition": {
        "recommended_name": {
            "id": "DOID:11934",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11934",
            "name": "head and neck cancer",
            "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
        },
        "synonyms": [
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck tumours",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head/neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "tumor of head and neck",
                "description": ""
            }
        ],
        "id": "DOID:11934"
    },
    "biomarker_component": [
        {
            "biomarker": "increased TNF level",
            "assessed_biomarker_entity_id": "P01375-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Tumor necrosis factor",
                "synonyms": [
                    {
                        "synonym": "N-terminal fragment"
                    },
                    {
                        "synonym": "NTF"
                    },
                    {
                        "synonym": "Tumor necrosis factor ligand superfamily member 2"
                    },
                    {
                        "synonym": "TNF-a"
                    },
                    {
                        "synonym": "Cachectin"
                    },
                    {
                        "synonym": "TNF-alpha"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "3074-2"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6309-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6309-2"
                },
                {
                    "id": "24481866",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/24481866",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Elevated levels of TNF-alpha were found in patients with head and neck squamous cell carcinoma (HNSCC). An upregulated TNF-alpha, in combination with CRP, was significantly related to shorter patient survival, independent of clinical stage. Findings indicate that TNF-alpha might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6309-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6309-2"
        },
        {
            "id": "24481866",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/24481866",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Elevated levels of TNF-alpha were found in patients with head and neck squamous cell carcinoma (HNSCC). An upregulated TNF-alpha, in combination with CRP, was significantly related to shorter patient survival, independent of clinical stage. Findings indicate that TNF-alpha might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6309-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6309-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Plasma tumor necrosis factor-alpha and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma.",
            "journal": "Journal of cancer research and clinical oncology",
            "authors": "Andersson BA, Lewin F, Lundgren J, Nilsson M, Rutqvist LE, Lofgren S, Laytragoon-Lewin N",
            "date": "2014",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24481866",
                    "url": "https://glygen.org/publication/PubMed/24481866"
                }
            ],
            "evidence": [
                {
                    "id": "AN6307-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6309-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}